NF-kappaB mediated transcriptional repression of acid modifying hormone gastrin.
Helicobacter pylori is a major pathogen associated with the development of gastroduodenal diseases.It has been reported that H.pylori induced pro-inflammatory cytokine IL1B is one of the various modulators of acid secretion in the gut.Earlier we reported that IL1B-activated NFkB down-regulates gastrin, the major hormonal regulator of acid secretion